Dr John Walter, our artist in residence, holds a Wellcome Trust Large Arts Award "CAPSID" with Greg. John's work is bright, witty, intelligent and sometimes hilariously inappropriate.
CAPSID
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The examples on this page will be featured in the CAPSID exhibition from , (The Gallery and Dilston Grove in Southwark Park). And at from 10 November 2018 - 6 January 2019.
For more information on the project visit John's . You can also read the articles in:
.More of John's work can be seen at his website .
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Viruses evade our intracellular defenses through a process we call cloaking.
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Stills from the film 'Virus Walks Into A Bar' (2018) with cameos from some of the Towers group! Viral entry receptors in yellow. Innate immune pattern recognition receptors in pink.
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Capsid arrives at the bar.
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Viral DNA synthesis
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Capsid would like a drink of CPSF6. He's uncoating at the Nuclear Pore Complex (bar).
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Capsid is looking to recruit his cofactorsÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌý
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Are pentamers important for cofactor binding, do we have a good pentamer structure?
Can you tell what a protein is by looking at its structure? Eg the CA hexamer. We don't think so.
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The process by which newly formed viruses leave infected cells is called budding. We work on a protein called tetherin that tethers the new virions preventing them from leaving to infect new cells.
Budding (googly eyes). Acrylic, ink, PVA, expanding foam filler, doll, organza, shrinkies, papier-mâché, silicone, foam and floam on circular canvas. 87 x 140 x 10cm
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What are the capsid hexamers for? Do they import nucleotides to fuel encapsidated DNA synthesis, or not?ÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌý
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Does HIV-1 only have 1 packaging sequence or are there lots of RNA-CA contacts? Is this how RT influences uncoating? Very interesting questions.
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Cofactors are non viral proteins that help the virus infect cells. Host proteins often changes the shape of the viral protein in a process called allostery. What allosteric effects does CypA have on the HIV hexamer?
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Two pictures from the Cytoplasm series. Chaos or totally organised. How does HIV-1 see it?
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Viral cofactors or restriction factors - hospitality or hostility? Or both?
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CAPSID at 'Home', Manchester
CAPSID has opened at the 'Home' Gallery in Manchester with over 1000 people through the doors on its first day providing the Gallery with its most successful opening to date.
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