Collaborations
MRC Laboratory of Molecular Biology, Cambridge
Jacques DA, McEwan WA, Hilditch L, Price AJ, Towers GJ, James LC. . Nature. 2016 Aug 18;536(7616):349-53. Epub 2016 Aug 10.
Rasaiyaah, J., C. P. Tan, A. J. Fletcher, A. J. Price, C. Blondeau, L. Hilditch, D. A. Jacques, D. L. Selwood, L. C. James, M. Noursadeghi and G. J. Towers. 2013. . Nature (2013) doi:10.1038/nature12769
Bichel, K., A. J. Price, T. Schaller, G. J. Towers, S. M. Freund, and L. C. James. 2013. . Retrovirology 10:81.
Price, A. J., A. J. Fletcher, T. Schaller, T. Elliot, K. Lee, V. N. Kewalramani, J. Chin, G. J. Towers, and L. C. James. 2012. . PLoS pathogens 8:e1002896
Caines, M. E., K. Bichel, A. J. Price, W. A. McEwan, G. J. Towers, B. J. Willett, S. M. Freund, and L. C. James. 2012. . Nat Struct Mol Biol 19:411-416.
Ylinen, L. M., Price, A. J., Rasaiyaah, J., Hue, S., Rose, N. J., Marzetta, F., James, L. C. & Towers, G. J. 2010. . PLoS Pathogens 6: e1001062
Mallery, D. L., W. A. McEwan, S. R. Bidgood, G. J. Towers, C. M. Johnson, and L. C. James. 2010. . Proceedings of the National Academy of Sciences of the United States of America 107:19985-19990.
Price, A. J., F. Marzetta, M. Lammers, L. M. J. Ylinen, T. Schaller, S. J. Wilson, G. J. Towers and L. C. James. 2009. . Nature Struct Mol Biol 16: 1036-42
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Division of Infection and Immunity, Ïã¸ÛÁùºÏ²Ê
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Mlcochova P, Watters SA, Towers GJ, Noursadeghi M, Gupta RK. Retrovirology. 2014 Mar 21;11:25. doi: 10.1186/1742-4690-11-25.
Towers GJ, Noursadeghi M. . Cell Host Microbe. 2014 Jul 9;16(1):10-8. doi: 10.1016/j.chom.2014.06.009.
Mlcochova P, Watters SA, Towers GJ, Noursadeghi M, Gupta RK.. Retrovirology. 2014 Mar 21;11:25. doi: 10.1186/1742-4690-11-25.
Rasaiyaah, J., C. P. Tan, A. J. Fletcher, A. J. Price, C. Blondeau, L. Hilditch, D. A. Jacques, D. L. Selwood, L. C. James, M. Noursadeghi and G. J. Towers. 2013. . Nature (2013) doi:10.1038/nature12769
Hughes R, Towers G, Noursadeghi M. Rev Med Virol. 2012 Jul;22(4):257-66. doi: 10.1002/rmv.1708. Epub 2012 Feb 22. Review.
Tomlinson, G. S., H. Booth, S. J. Petit, E. Potton, G. J. Towers, R. F. Miller, B. M. Chain, and M. Noursadeghi. 2012. PloS one 7:e40348.
Schaller, T., K. E. Ocwieja, J. Rasaiyaah, A. J. Price, T. L. Brady, S. L. Roth, S. Hue, A. J. Fletcher, K. Lee, V. N. Kewalramani, M. Noursadeghi, R. G. Jenner, L. C. James, F. D. Bushman, and G. J. Towers. 2011.. PLoS Pathog 7:e1002439
Tsang, J., B. M. Chain, R. F. Miller, B. L. J. Webb, W. Barclay, G. J. Towers, D. R. Katz, and M. Noursadeghi. 2009.. AIDS 23:2255-63
Ylinen LM, Schaller T, Price A, Fletcher AJ, Noursadeghi M, James LC, Towers GJ. J Virol. 2009 Feb;83(4):2044-7. doi: 10.1128/JVI.01876-08. Epub 2008 Dec 10.
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Dr Stéphane Hué
Department of Infectious Disease Epidemiology, LSHTM
We collaborate with Stéphane to consider the genetics of host and virus using phylogenetic and positive selection techniques.
Monit C, Goldstein RA, Towers G, Hué S. AIDS Res Hum Retroviruses. 2015 Oct;31(10):947. doi: 10.1089/AID.2015.0150. Epub 2015 Jul 22.
Schaller, T., K. E. Ocwieja, J. Rasaiyaah, A. J. Price, T. L. Brady, S. L. Roth, S. Hue, A. J. Fletcher, K. Lee, V. N. Kewalramani, M. Noursadeghi, R. G. Jenner, L. C. James, F. D. Bushman, and G. J. Towers. 2011. PLoS Pathog 7:e1002439
Gupta, K. R., S. Hué, T. Schaller, E. Verschoor, D. Pillay and G. J. Towers. 2009. . PloS Pathogens 5:e1000443
Ylinen, L. M., Price, A. J., Rasaiyaah, J., Hue, S., Rose, N. J., Marzetta, F., James, L. C. & Towers, G. J. 2010. . PLoS Pathogens 6: e1001062
Fletcher AJ, Hué S, Schaller T, Pillay D, Towers GJ. J Virol. 2010 Dec;84(23):12463-8. doi: 10.1128/JVI.01514-10. Epub 2010 Sep 22.
Hué S, Gray ER, Gall A, Katzourakis A, Tan CP, Houldcroft CJ, McLaren S, Pillay D, Futreal A, Garson JA, Pybus OG, Kellam P, Towers GJ. Retrovirology. 2010 Dec 20;7(1):111. doi: 10.1186/1742-4690-7-111.
Katzourakis A, Hué S, Kellam P, Towers GJ. J Virol. 2011 Oct;85(20):10909-13. doi: 10.1128/JVI.00827-11. Epub 2011 Aug 17.
Schaller T, Hué S, Towers GJ. J Virol. 2007 Nov;81(21):11713-21. Epub 2007 Aug 29.
Division of Infection and Immunity, Ïã¸ÛÁùºÏ²Ê
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Mlcochova P, Caswell SJ, Taylor IA, Towers GJ, Gupta RK. . EMBO J. 2018 Jan 4;37(1):50-62. doi: 10.15252/embj.201796880. Epub 2017 Oct 30.
Mlcochova P, Sutherland KA, Watters SA, Bertoli C, de Bruin RA, Rehwinkel J, Neil SJ, Lenzi GM, Kim B, Khwaja A, Gage MC, Georgiou C, Chittka A, Yona S, Noursadeghi M, Towers GJ, Gupta RK. EMBO J. 2017 Mar 1;36(5):604-616. doi: 10.15252/embj.201696025. Epub 2017 Jan 25.
Mlcochova P, Watters SA, Towers GJ, Noursadeghi M, Gupta RK. Retrovirology. 2014 Mar 21;11:25. doi: 10.1186/1742-4690-11-25.
Gupta, R. K., Kohli, A., McCormick, A. L., Towers, G. J., Pillay, D.,and C. M. Parry. 2010. . AIDS 24:1651-5
Gupta, R. K. and G. J. Towers. 2009. Cell Host and Microbes 5: 393-5
Gupta, K. R., S. Hué, T. Schaller, E. Verschoor, D. Pillay and G. J. Towers. 2009. . PloS Pathogens 5:e1000443
Gupta, R. K., P. Mlcochova, A. Pelchen-Matthews, S. J. Petit, G. Mattiuzzo, D. Pillay, Y. Takeuchi, M. Marsh, and G. J. Towers. 2009. . Proc Natl Acad Sci U S A 106: 20889-20894
Division of virology, NIBSC
We collaborate with Neil and his colleagues at the National Institute for Biological Standards, part of the MHRA, to understand the correlates of protection of live attenuated vaccination of non-human primates with simian immunodeficiency virus. Neil has found that a live attenuated vaccine provides particularly effective protection from homologous and heterologous lentivirus challenge. Our work has considered the role of restriction factors and the innate immune system generally in protection with the view to developing an HIV-1 vaccine that produces a similar protective response.
Ferguson D, Mattiuzzo G, Ham C, Stebbings R, Li B, Rose NJ, Mee ET, Smith D, Page M, Cranage MP, Almond N, Towers GJ, Berry NJ. PLoS One. 2014 Aug 27;9(8):e104390. doi: 10.1371/journal.pone.0104390. eCollection 2014.
Mattiuzzo G, Rose NJ, Almond N, Towers GJ, Berry N. . Gen Virol. 2013 Mar;94(Pt 3):606-11. doi: 10.1099/vir.0.047795-0. Epub 2012 Nov 14.
Berry NJ, Marzetta F, Towers GJ, Rose NJ. . 2012 Apr;64(4):267-78. doi: 10.1007/s00251-011-0585-x. Epub 2011 Nov 29.
Berry N, Ham C, Mee ET, Rose NJ, Mattiuzzo G, Jenkins A, Page M, Elsley W, Robinson M, Smith D, Ferguson D, Towers G, Almond N, Stebbings R. PLoS One. 2011;6(8):e23092. doi: 10.1371/journal.pone.0023092. Epub 2011 Aug 10.
Prof David Selwood
Wolfson Institute for Biomedical Research, Ïã¸ÛÁùºÏ²Ê
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Culley S, Towers GJ, Selwood DL, Henriques R, Grove J. . Viruses. 2016 Jul 21;8(7). pii: E201. doi: 10.3390/v8070201.
Warne J, Pryce G, Hill JM, Shi X, Lennerås F, Puentes F, Kip M, Hilditch L, Walker P, Simone MI, Chan AW, Towers GJ, Coker AR, Duchen MR, Szabadkai G, Baker D, Selwood DL. J Biol Chem. 2016 Feb 26;291(9):4356-73. doi: 10.1074/jbc.M115.700385. Epub 2015 Dec 17.
Rasaiyaah, J., C. P. Tan, A. J. Fletcher, A. J. Price, C. Blondeau, L. Hilditch, D. A. Jacques, D. L. Selwood, L. C. James, M. Noursadeghi and G. J. Towers. 2013. . Nature (2013) doi:10.1038/nature12769
IrsiCaixa, Institut de Reserca de la Sida, Barcelona
We collaborate with Julia to understand the biology of HIV antigen presentation and antiviral mechanisms of TRIM5.
Jimenez-Moyano E, Ruiz A, Kløverpris HN, Rodriguez-Plata MT, Peña R, Blondeau C, Selwood DL, Izquierdo-Useros N, Moris A, Clotet B, Goulder P, Towers GJ, Prado JG. J Virol. 2016 Sep 12;90(19):8552-62. doi: 10.1128/JVI.00819-16. Print 2016 Oct 1.
Kløverpris HN, Payne RP, Sacha JB, Rasaiyaah JT, Chen F, Takiguchi M, Yang OO, Towers GJ, Goulder P, Prado JG. 2013. Journal of Virology 87(5):2628-38
Prof Richard Milne
Department of Virology, Ïã¸ÛÁùºÏ²Ê Medical School
Richard leads infection and immunity teaching at Ïã¸ÛÁùºÏ²Ê and is recipient of numerous teaching awards. Together with Greg and the Towers lab, he is developing a research-led teaching programme in which senior investigators and post-docs teach undergraduate lectures based on their most recent and exciting discoveries. We aim not only to teach science facts but also to teach students how to think like scientists. Richard and Greg run a London-wide monthly seminar programme: Virtual Virology, and a public engagement programme for school children.
Sumner RP, Thorne LG, Fink DL, Khan H, Milne RS, Towers GJ. Front Immunol. 2017 Oct 6;8:1246. doi: 10.3389/fimmu.2017.01246. eCollection 2017.
Blondeau, C., A. Pelchen-Matthews, P. Mlcochova, M. Marsh, R. S. Milne, and G. J. Towers. Tetherin Restricts Herpes Simplex Virus Type 1 and is Antagonised by Glycoprotein J.Virol. 2013 Sep 25
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Dr Joe Grove
Division of Infection and Immunity, Ïã¸ÛÁùºÏ²Ê
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Siân Culley,ÌýGreg J Towers,ÌýDavid L Selwood,ÌýRicardo Henriques,ÌýJoe Grove VirusesÌý2016 Jul 21;8(7):201.Ìýdoi: 10.3390/v8070201.
Division of Infection and Immunity, Ïã¸ÛÁùºÏ²Ê
Richard is an computational biologist in our Dept at Ïã¸ÛÁùºÏ²Ê who studies virus and host evolution. We believe that biological data make most sense when considered in the context of evolution. In collaboration with Richard we consider ways to ask questions that combine evolutionary and molecular biology experimental approaches.
Monit C, Goldstein RA, Towers G, Hué S. AIDS Res Hum Retroviruses. 2015 Oct;31(10):947. doi: 10.1089/AID.2015.0150. Epub 2015 Jul 22.
University Of Surrey
Carlos studies pox viruses in his group at the University of Surrey. We collaborate with Carlos because pox viruses manipulate DNA sensing and comparing and contrasting replication and innate immune evasion strategies between pox viruses and retroviruses is very informative.
Georgana I, Sumner RP, Towers GJ, Maluquer de Motes C. . J Virol. 2018 Feb 28. pii: JVI.02145-17. doi: 10.1128/JVI.02145-17.
Division of Infection and Immunity, Ïã¸ÛÁùºÏ²Ê
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Virology Research Services Ltd
ICH and Great Ormond Street Hospital
We collaborate with Waseem on developing novel gene therapy based approaches to treat HIV infection in children.
Chan E, Towers GJ, Qasim W. . 2014 Jan 14;6(1):243-63. doi: 10.3390/v6010243. Review.
Chan, E., T. Schaller, A. Eddaoudi, H. Zhan, C. P. Tan, M. Jacobsen, A. J. Thrasher, G. J. Towers, and W. Qasim. 2012. . Human gene therapy. 23:1176-85
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Faculty of Medicine, University of New South Wales
Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling.Ìý Fletcher AJ, Vaysburd M, Maslen S, Zeng J, Skehel JM, Towers GJ, James LC. Cell Host Microbe. 2018 Dec 12;24(6):761-775.e6. doi: 10.1016/j.chom.2018.10.007. Epub 2018 Nov 29.Ìý PMID:30503508.
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis.Ìý Mallery DL, Márquez CL, McEwan WA, Dickson CF, Jacques DA, Anandapadamanaban M, Bichel K, Towers GJ, Saiardi A, Böcking T, James LC.Ìý Elife. 2018 May 31;7. pii: e35335. doi: 10.7554/eLife.35335. PMID:29848441
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.Ìý Jacques DA, McEwan WA, Hilditch L, Price AJ, Towers GJ, James LC.Ìý Nature. 2016 Aug 18;536(7616):349-53. Epub 2016 Aug 10.Ìý PMID: 27509857
Dr Che Colpitts
Queens University, Ontario, Canada
Che spent three years as a research fellow with us funded by Canadian fellowships and a grant from the Ïã¸ÛÁùºÏ²Ê/Ïã¸ÛÁùºÏ²ÊH Biomedical Research Centre. Che taught us how to work on flaviviruses with a focus on Hepatitis C (HCV). Che worked out that if you inhibit HCV with cyclosporines then the antiviral protein PKR is activated to provide activiral acivity via IRF1 published in eLife. Che now helps us understand how innate immunity works against Dengue Virus funded by an MRC project grant co-written with Che. We were sorry to see Che go but very happy to see her success in setting up and funding her own lab at Queens University in Canada.
Colpitts CC, Ridewood S, Schneiderman B, Warne J, Tabata K, Ng CF, Bartenschlager R, Selwood DL, Towers GJ. 2020 Hepatitis C virus exploits cyclophilin A to evade PKR. ÌýElife. Jun 16;9:e52237. doi: 10.7554/eLife.52237.
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MRC-University of Glasgow Centre for Virus Research (CVR)
EM photographer
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Quantitative Biosciences Institute (QBI) at the University of California San Francisco (UCSF)
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2022 Jan 10;5(4):e202101200. doi: 10.26508/lsa.202101200. Print 2022 Apr.
Life Science Alliance2022 Feb;602(7897):487-495. doi: 10.1038/s41586-021-04352-y. Epub 2021 Dec 23.
Nature,2021 Jun 7;2021.06.06.446826. doi: 10.1101/2021.06.06.446826. Preprint
. BioRxiv,