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Other outputs

This is a partial list of outputs that are not peer-reviewed publications

Tuberculosis sequencing pipeline resources (2023)ÌýFurther to the item below (Workshop and resources: Oxford Nanopore sequencing for tuberculosis, 2022),Ìý Linzy Elton has developed webpages and videos designed to help people build a pragmatic pipeline for whole genome sequencing (WGS) for sites with little/no access to larger scale Illumina sequencing platforms.ÌýThe pipeline is primarily designed to identify antimicrobial resistances (e.g. for hard to treat cases) and lineages (e.g. to identify relapse vs reinfection or non-tuberculous mycobacteria. This is likely to be small-scale (at least at first), to be used in house as an alternative to the potentially expensive or logistically difficult Illumina platform.ÌýThe information is available on the PANDORA website ()

Report of the technical consultation on innovative clinical trial designs for evaluating new TB preventive treatments.Ìý(2022)ÌýVirtual meeting,Ìý15-17ÌýSeptemberÌý2021 (published 2022).Ìý World Health Organization (WHO) Global Tuberculosis Programme, in collaboration withÌýUniversity College London and other partners, convened a virtual technical consultationÌýfrom 15 to 17 September 2021 that focused on innovative clinical trial designs that could beÌýused for evaluating new tuberculosis (TB) preventive treatments (TPTs). The objectives ofÌýthe meeting were to identify and summarize challenges in designing future TPT trials and toÌýexplore innovative designs that could facilitate advances in biomedical TB preventiveÌýinterventions and would complement similar developments in other fields relevant to TBÌýprevention.ÌýDiscussions were organized in four main sessions:ÌýSession 1: Models of delivery;ÌýSession 2: Estimating the benefits and harms of TPT;ÌýSession 3: Trial design and analytical approaches;ÌýSession 4: Trial populations.ÌýYohhei Hamada and Molebogeng (Lele) Rangaka, both from the Institute forÌýGlobal Health and the Medical Research Council (MRC) Clinical Trials Unit at University CollegeÌýLondon (Ïã¸ÛÁùºÏ²Ê), drafted the concept note and helped organize the meeting. Elena Pallari andÌýGenevieve Wills, both also from the MRC Clinical Trials Unit at Ïã¸ÛÁùºÏ²Ê, served as meetingÌýrapporteurs. Others involved from Ïã¸ÛÁùºÏ²Ê includedÌýAngela Crook, David Dunn,ÌýBecky Turner and Ian White (MRC Clinical Trials Unit at Ïã¸ÛÁùºÏ²Ê).

WHO consolidated guidelines on tuberculosis: module 3: diagnosis: tests for TB infection. (2022)ÌýÌýYohhei Hamada and Lele Rangaka, with colleagues, led a series of systematic reviews that informed the development of the World Health Organization guidelines on the use ofÌýMycobacterium tuberculosisÌýantigen-based skin tests. The four reviews each addressed the accuracy, safety, costs and cost-effectiveness of, and feasibility, acceptability, and patient preferences for the use of the new skin tests. The guidelines and the systematic review reports are available on theÌý.

Workshop and resources: Oxford Nanopore sequencing for tuberculosis. (2022)Ìý. This workshop took place 22-25th August 2022 at the National Institute for Medical Research (NIMR) at Muhimbili, Dar es Salaam, Tanzania. It was jointly run by Ïã¸ÛÁùºÏ²Ê and NIMR.ÌýThe aim of the workshop was to provide theoretical and practical training for all of the steps in the tuberculosis Oxford Nanopore Technologies (ONT) sequencing pipeline, from CTAB DNA extraction, DNA quantification best practice, library preparation and setting up a sequencing run, and analysing sequencing data. The workshop was run using a combination of theoretical, laboratory and bioinformatic sessions, with discussion and Q&A sessions throughout the workshop. The website includes links toÌýthe presentations and workshop handbook,Ìýhow to set up a sequencing laboratory (aimed at resource constrained laboratories), how to learn sequencing bioinformatics, andÌýtutorial videos on ONT sequencing.Ìý The Ïã¸ÛÁùºÏ²Ê team were Linzy Elton and Sylvia Rofael from the Ïã¸ÛÁùºÏ²Ê Centre for Clinical Microbiology.

TB and COVID-19 discussionÌý (2020) (/tb/how-will-covid-19-affect-tb-patients-and-control)

  • Video (YouTubeÌý)
  • Audio (SoundcloudÌý)

The IMPACT study - Voices from the Front Line (2020) (/tb/impact-study)

  • Presentation ()

Blog: JoiHok!: New Ïã¸ÛÁùºÏ²Ê graduate sets up TB initiative in Kolkata (2020) ()

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