Working with Wild-type (Unmodified) Agents

This page provides guidance on working with Wild-type biological agents at 香港六合彩.

Before starting work

Wild type (unmodified)听microorganism risk assessment is carried out to identify the necessary controls that are required to restrict the exposure of employees to hazard group 2 and hazard group 3 microorganisms or materials such are tissues derived from humans or animals that could harbour pathogens hazardous to human health or the environment.

The wild type microoorganism risk assessment must consider the following:

Identification of the听Hazard Group听(HG) of the microorganisms.
- Information on Hazard Groups can be found in the听.
罢丑别听Containment Level听(CL) required for handling the microorganisms.
- Additional security requirements are required if the microorganism is listed in听. [does this relate to purchasing, storing etc?)
Safe storage of the biological agent.
- Is the microorganism listed under the听.听[what are the implications?].

Speak to your local Genetic Modification Safety Officer (GMSO) or the听Biological and Chemical Safety team听to ensure that you are aware of the requirements before ordering any biological agents including wildtype听(unmodified) microorganisms as well as tissues, fluids and other materials derived from humans or animals听

Mandatory training听

Before working with Hazard Group microorganisms, you must complete the formal training:

> Principles of laboratory safety
> Principles and practice of biosafety

Areas working with HG2 and HG3 microorganisms will have specific training for their laboratories and activities.

Guidance on completing听谤颈蝉办听补蝉蝉别蝉蝉尘别苍迟

riskNET: Risk Assessment of Biological agents and plants provides guidance on completing and approving biological agent and plant risk assessments, covering genetically modified and wild type work activities.

Work with Hazard Group 1听

Hazard Group 1 work involves biological agents that have not been genetically modified and are unlikely to cause diseases in a healthy individual. Activities with Hazard Group 1 wild-type听biological agents do not require enhanced biosafety controls and can be used in most labs as long as good lab safety principles are followed.

For advice on completing the form refer to听the 搁颈蝉办听补蝉蝉别蝉蝉尘别苍迟 page. Once the assessor has completed, the risk assessment should be approved by the department. The risk assessment is typically assigned to听the PI in control of the work and the local Genetic Modification Safety Officer (GMSO). If the PI is the assessor, then a peer with knowledge and experience of this type of work can review and approve the risk assessment to confirm the technical detail and the controls to be implemented as suitable.

Copying an existing risk assessment

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听

Creating a new risk assessment

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听

Work with Hazard group 2 and听3听

Before starting work for the first time and bringing the biological agent on-site:

Identify the Hazard Group and Containment Level for the microorganisms you will be using to ensure the听right level of containment is available. Information on the hazard groups can be found in the听 (gov.uk).
If the biological agent is listed in 听and/or听听there are additional security requirements.听听Speak to your Departmental Safety Officer and the Biological and Chemical Safety team to ensure that you are aware of the requirements before ordering.
Check riskNET to see if there is a risk assessment in place which is similar to the work proposed.听 If a similar risk assessment exists, copy the risk assessment to get a new reference number and amend the risk assessment to reflect the new work.听
>

听

If a risk assessment doesn't exist in riskNET, select听the relevant specialist risk assessment form for Hazard Group 2 or 3. For advice on completing the form refer to听the 搁颈蝉办听补蝉蝉别蝉蝉尘别苍迟听page.

>

听

When completing the risk assessment the assessor identifies the approvers who will authorise the assessment. Typically this is the PI who is in control of the work and the local Genetic Modification Safety Officer (GMSO). If the PI is the assessor, then a peer with knowledge and experience of this type of work can听 approve the risk assessment. This will ensure听the technical detail and the controls to be implemented are听suitable.
Once听the risk assessment has been authorised by the approvers listed in the risk assessment,听HG听2 and听HG 3 risk assessment will be reviewed by the GMBSSC.听 Only when this approval is provided can the work commence.

Additonal approval for HG 3 and named HG2 microoorganisms

Once the approvers listed in the GM risk assessment have approved the risk assessment, approval is also required by the GMBSCC before the risk assessment is fully authorised.

Work with the following agents requires approval from the Health and Safety Executive before the GMBSCC can authorise the risk assessment.听This is because these HG2 microorganisms are spread by aerosol. Submission to the HSE requires the completion of a CBA1 form which the Biological Safety Officer will issue to you. The HSE requires 20 days to review the risk assessment. If no concerns are raised the risk assessment will be fully authorised and work can commence.

Bordetella pertusis

Corynebacterium diptheriae

听

Work with Hazard Group 2 and 3 microorganisms听cannot begin until a risk assessment has been authorised by the GMBSCC. Only once Risk Assessment has听been fully authorised can work commence.