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MRC Prion Unit and Institute of Prion diseases

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Emmanuelle 痴颈谤茅

Emmanuelle Vire

e.vire@prion.ucl.ac.uk

Tel: 020 7679 5094
Courtauld Building, Room G01

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Research Synopsis

We explore if epigenetics is a hallmark of protein-based inheritance in neurodegeneration. Our research specifically investigates epigenetic mechanisms in human prion diseases. We employ a large array of technologies (transcriptomics, epigenomics, cell-based assays, animal models, patients samples) to determine if, where, when and how epigenetics contribute to disease susceptibility, onset, and progression. Using next-generation technologies we profile DNA, RNA, and histone modifications and identify disease-specific gene (coding and non-coding) signatures and pathways. Some of our current projects also involve machine learning, nanopore sequencing, small molecule inhibitor and genome editing.

Ultimately, our research aims to uncover protein-based inheritance signatures that could be manipulated through drugs and/or lifestyle changes.

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EV fig

Manhattan plot for an epigenome-wide association of DNA methylation in sporadic CJD.

Selected Publications


Dabin L*, Guntoro F*, CampbellT, B茅licardT, SmithAR, SmithRG, RaybouldR, SchottJM LunnonK, SarkiesP, CollingeJ, MeadM and 痴颈谤茅E (2020).
* denotes equal contribution; Acta Neuropathol. 2020 Sep 12. doi: 10.1007/s00401-020-02224-9.


Norsworthy P, Thompson A, Mok T, Paterson R, Schott J, Collinge J, Mead S, 痴颈谤茅 E. (2020)
Nat Commun 11, 3960.


痴颈谤茅 E*, Jones E*, Hummerich H*, UphillJ, DimitriadisA, SpeedyH, CampbellT, NorsworthyP, QuinnL, WhitfieldJ, LinehanJ, et al. (2020).
* denotes equal contribution; listed as Jones et al in Pubmed; Lancet Neurology, 2020 Oct;19(10):840-848. doi: 10.1016/S1474-4422(20)30273-8.鈥�


Amaral PP, Leonardi T, Han N, 痴颈谤茅 E, Gascoigne DK, Arias-Carrasco R, B眉scher M, Pandolfini L, Zhang A, Pluchino S, Maracaja-Coutinho V, Nakaya HI, Hemberg M, Shiekhattar R, Enright AJ, Kouzarides T. Genome Biol. 2018 Mar 15;19(1):32. doi: 10.1186/s13059-018-1405-5.


痴颈谤茅 E, Curtis C, Davalos V, Git A, Robson S, Villanueva A, Vidal A, Barbieri I, Aparicio S, Esteller M, Caldas C, Kouzarides T.
Mol Cell. 2014 Apr 10;54(1):203. doi: 10.1016/j.molcel.2014.03.041.


痴颈谤茅 E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden JM, Bollen M, Esteller M, Di Croce L, de Launoit Y, Fuks F.
Nature. 2006 Feb 16;439(7078):871-4.
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