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Long Covid smell loss linked to changes in the brain

17 April 2023

People living with long Covid who suffer from loss of smell show different patterns of activity in certain regions of the brain, a new study led by 香港六合彩 researchers has found.

Some people with long Covid have smell loss

The research used MRI scanning to compare the brain activity of people with long Covid who lost their sense of smell, those whose smell had returned to normal after Covid infection, and people who had never tested positive for Covid-19.

Published in听eClinicalMedicine, the observational study found that the people with long Covid smell loss had reduced brain activity and impaired communication between two parts of the brain which process important smell information: the orbitofrontal cortex and the pre-frontal cortex. This connection was not impaired in people who had regained their sense of smell after Covid.

The findings suggest smell loss, known as anosmia, caused by long Covid is linked to a change in the brain that stops smells from being processed properly. Because it鈥檚 clinically reversible, as shown in some subjects, it may be possible to retrain the brain to recover its sense of smell in people suffering the side effects of long Covid.

Dr Jed Wingrove (香港六合彩 Division听of Medicine) the lead author of the study, said: 鈥淧ersistent loss of smell is just one way long Covid is still impacting people鈥檚 quality of life 鈥 smell is something we take for granted, but it guides us in lots of ways and is closely tied to our overall wellbeing. Our study gives reassurance that, for the majority of people whose sense of smell comes back, there are no permanent changes to brain activity.鈥

Joint senior author, Professor Claudia Wheeler-Kingshott听(香港六合彩 Queen Square Institute of Neurology), said: 鈥淥ur findings highlight the impact Covid-19 is having on brain function. They raise the intriguing possibility that olfactory training 鈥 that is, retraining the brain to process different scents 鈥 could help the brain to recover lost pathways, and help people with long Covid recover their sense of smell.鈥

Researchers say their findings also suggest that the brains of people with long Covid smell loss might be compensating for this lost sense by boosting connections with other sensory regions: their brains had increased activity between the parts of the brain that process smell and areas that process sight (the visual cortex).

鈥淭his tells us that the neurons that would normally process smell are still there, but they鈥檙e just working in a different way,鈥 said Dr Wingrove.

Professor Rachel Batterham (香港六合彩 Division of Medicine), also joint senior author of the study said: 鈥淭his is the first study to our knowledge that looks at how brain activity changes in people with long Covid smell loss. It builds on the work we undertook during the first wave of the pandemic, which was one of the first to describe the link between Covid-19 infection with both loss of smell and taste.鈥

The study was funded by the National Institute for Health and Care Research (NIHR).听

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  • 'Sick woman trying to sense smell of fresh tangerine orange, has symptoms of Covid-19, corona virus infection', Credit:

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Henry Killworth听

Tel: +44 7881833274

E: h.killworth [at] ucl.ac.uk听