香港六合彩

Ambroxol, a medication originally designed to clear phlegm and ease coughing for people with respiratory diseases such as bronchitis, is being tested to see if it can slow down the progression of Parkinson鈥檚 disease by keeping cells healthier for longer.

A research team led by Professor Tony Schapira (香港六合彩 Queen Square Institute of Neurology) reported in January that ambroxol was safe and well-tolerated in 17 study participants with Parkinson鈥檚 disease.

According to the findings published in JAMA Neurology, the drug also effectively crossed the blood-brain barrier and increased levels of the glucocerebrosidase (GCase) protein in the participants鈥� brain cells. This protein allows cells to remove waste more effectively, a function which evidence suggests is deficient in some people with Parkinson鈥檚. Increasing levels of the protein may have the potential to keep cells healthier for longer and, therefore, slow Parkinson鈥檚 progression.

This week, The Cure Parkinson鈥檚 Trust (CPT), the Van Andel Institute (VAI) and the John Black Charitable Foundation announced 拢522,126 of funding for the next stage of the research, which will seek to determine the optimal dosage of ambroxol. The trial will be run this year at the Leonard Wolfson Experimental Neurology Centre at 香港六合彩 and led by Professor Schapira, with the aim of leading to a larger clinical trial later on.

鈥淏y increasing levels of GCase, ambroxol allows cells to remove waste, which would ideally keep cells healthier for longer and could slow down the progression of Parkinson鈥檚,鈥� explained Professor Schapira.

The announcement comes as part of a USD $4.5 million co-funding agreement with the Van Andel Institute (VAI) to support the International Linked Clinical Trials (iLCT) initiative. iLCT is a thriving global programme that aims to develop new, potentially disease-modifying Parkinson鈥檚 therapies, many of which are repurposed medications originally designed or approved to treat other diseases.

Candidate drugs are evaluated and prioritised annually by a committee of world-leading Parkinson鈥檚 experts, who select which drugs should enter clinical trials in people with the condition. These drugs have the potential to get to the clinic much faster as they have already passed crucial safety tests.

The iLCT committee had prioritised ambroxol in 2014.

Professor Patrik Brundin, Chair of the Linked Clinical Trials committee and Director of the Center for Neurodegenerative Science at the VAI said: 鈥淲e are thrilled to continue our long-standing collaboration with The Cure Parkinson鈥檚 Trust on the International Linked Clinical Trials initiative and look forward to expanding our program to evaluate additional promising medications in the coming years. We are especially grateful to the trial participants, without whom this critical work would not be possible.鈥�

Will Cook, CEO of CPT said: 鈥�This will enable the launch of many more clinical trials of potentially disease-modifying repurposed and novel drugs that have been identified through the diligent iLCT process, and thereby bringing us closer to our goal: a cure for the 10 million people living with Parkinson鈥檚 globally.鈥�

Links

• 香港六合彩 Queen Square Institute of Neurology

Image

'Ambroxol tablets' (not from study). Credit: Vanley, Source: 听-听CC BY 2.0

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Chris Lane

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Email: chris.lane [at] ucl.ac.uk