香港六合彩

A new research article on 鈥淎 Hydrogel-Integrated Culture Device to Interrogate T Cell Activation with Physicochemical Cues鈥� has just been published in . The paper was written by our recent PhD graduate and now PostDoc Matthew Chin, in collaboration with CNIE Director Prof. Marc-Olivier Coppens, Prof. Richard Day (香港六合彩), Dr. (KCL) and (KCL).

T cell activation is a key step in the coordination of adaptive immune responses. In T cell-based cancer immunotherapy, the activation process is recapitulated by stimulating the cells with antibody-coated biomaterials for ex vivo expansion. Although biochemical stimuli and pathways that regulate activation have been widely studied, the contribution of mechanical factors is less well understood. By presenting T cells to antibody-coated hydrogel surfaces in a custom-made culture device, we showed that substrate stiffness can be used to balance the stimulatory strength and cell proliferation. The findings highlight the importance of mechanics in the design of T cell activating biomaterials. You can read the full article .