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Receptors and Synaptic Signalling (ANAT0018)

Key information

Faculty
Faculty of Life Sciences
Teaching department
Division of Biosciences
Credit value
15
Restrictions
The module is compulsory for MSc Neuroscience students. It may also be taken as an option by students on the Dual Masters in Brain and Mind Sciences, MRes Biosciences or the MSc Biomedical Sciences.
Timetable

Alternative credit options

There are no alternative credit options available for this module.

Description

In a series of research lectures given by Ïã¸ÛÁùºÏ²Ê neuroscientists you will learn how the fundamental biophysical properties of neurones and their ion channels, neurotransmitters and their receptors contribute to neuronal processing in health and disease.

There is also an optional introductory week focussing on the passive properties (electrical equivalent circuit of a neurone, length constant, time constant, Nernst potentials etc.).

Indicative lecture titles

Week 1: voltage-gated ion channels

  • Introduction to Ion Channels
  • Voltage-gated Ca2+ -channels: their role in disease
  • Voltage-gated Na+-channels: targets for anti-epileptics and neuroprotectors
  • Voltage-gated K+-channels: from structure to disease

Week 2: chemical neurotransmission

  • Presynaptic mechanisms
  • Nicotinic receptors
  • Analysis of gating and kinetics of ligand-gated ion channels: theory and applications
  • Ligand-gated ion channels in synaptic transmission

Week 3: neuronal inhibition

  • Introduction to neuronal inhibition
  • GABAA receptors in central transmission
  • GABAA receptor functioning and trafficking
  • GABABR's: function and dynamics

Week 4: synaptic integration and plasticity

  • Introduction to synaptic integration and plasticity
  • Integration of synaptic transmission
  • Modulation of encoding and integrative properties of neurones by K+-channels
  • Memories are made of this...

Module deliveries for 2024/25 academic year

Intended teaching term: Term 1 ÌýÌýÌý Postgraduate (FHEQ Level 7)

Teaching and assessment

Mode of study
In person
Methods of assessment
50% Exam
50% Coursework
Mark scheme
Numeric Marks

Other information

Number of students on module in previous year
45
Module leader
Dr Andrew Batchelor
Who to contact for more information
a.batchelor@ucl.ac.uk

Last updated

This module description was last updated on 8th April 2024.

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