Immunosenescence and Ageing
Our work
For the last 15 years, the Akbar Lab has focused on mechanisms of immune decline during ageing. We have identified a key role of p38 MAP kinase signalling in regulating both nutrient and senescence sensing pathways in human T cells.Ìý
We also developed new technology for investigating immunity in human skin in vivo that have been adopted by other research groups in both academia and the biotech industry. Current collaborations using these methods include the University of Arizona, The Rockefeller University (New York) and the National University of Singapore.Ìý
The interaction between clinicians and scientists leads to the translational aspects of our work. This has procured a £3.2M MRC Experimental Medicine Grant to investigate responses to recall antigen challenge in the skin of older humans after blocking p38MAP kinase.
Our experts
Mr Hugh Trahair
Terence Ma (PhD student)
(PhD student)
Collaborators
- Janet Lord, University of Birmingham
- Tao Dong, University of Oxford
- Menna Clatworthy, University of Cambridge
- David Mosser, University of Maryland
- James Krueger, The Rockefeller University
- Karolina Palucka, The Jackson Laboratory
- Paul Macaray, National University of Singapore
- Jonathan Crowston, National University of Singapore
Selected publications
- Lanna A, Gomes DCO, Muller-Durovic B, et al. (2017).Ìý Nat Immunol. 2017;18(3):354-363.
- Pereira BI, De Maeyer RPH, Covre LP, et al. (2020).Ìý 2020;21(6):684-694.
- Chambers ES, Vukmanovic-Stejic M, Shih BB, et al. (2021).Ìý Nat Aging. 2021;1(1):101-113.
PearceÌýDRR,ÌýAkarcaÌýAUU,ÌýDe MaeyerÌýRPH,Ìý¸é±ð»å»å²âÌý³Õ,Ìý´¡°ì²ú²¹°ùÌý´¡±·±·, et al. (2023) . Front. Oncol., Vol. 13.
Haston S,ÌýGonzalez-GualdaÌýE,ÌýMorsliÌýS ...ÌýAkbar, AN, et al.Ìý(2023). . Cancer Cell, Vol. 41 (7), pp. 1242-1260.e6.
- ³¢²¹±è³ó²¹²Ô³Ü·É²¹³ÙÌý±Ê,Ìý³Ò´Ç³¾±ð²õÌý¶Ù°ä°¿,Ìý´¡°ì²ú²¹°ùÌý´¡±·Ìý(2023). . Immunological Reviews, VolÌý316 (1),Ìýpp. 160-175.
- PallettÌýLJ,ÌýSwadlingÌýL,ÌýDinizÌýM,ÌýMainiÌýAA ...Ìý´¡°ì²ú²¹°ùÌý´¡, et al.Ìý(2023). . Nature 614, 334–342.
- LannaÌýA,ÌýVazÌýB,ÌýD'AmbraÌýC,ÌýValvoÌýS ... ´¡°ì²ú²¹°ùÌý´¡±·, et al.Ìý(2022). . Nat Cell Biol, 24, 1461–1474.
- De MaeyerÌýRPH,Ìý´¡°ì²ú²¹°ùÌý´¡±·Ìý(2022). . Nat Aging 2, 280–281 (2022).
- ¹ó¾±²¹°ù»åÌý³Ò,Ìý³§³Ù²¹±¹°ù¾±²Ô¾±»å±ð²õÌý³Õ,Ìý°ä³ó²¹³¾²ú±ð°ù²õÌý·¡³§,Ìý±á±ð²¹±¹±ð²âÌý³§,Ìý¹ó°ù±ð±ð³¾²¹²ÔÌý´¡,Ìýµþ²¹±ô±ôÌý¸é,Ìý´¡°ì²ú²¹°ùÌý´¡±·Ìý(2021). . Nat Rev Urol 18, 597–610.
Funding and partnerships
Ìý
Media
Contact DetailsÌý
Professor Arne AkbarÌý
a.akbar@ucl.ac.ukÌý
Postal Address:Ìý
University College LondonÌý
Windeer Institute
43 Clevelan StÌý
London
W1T 4JF