The WAVE puts binding kinetics analysis at your fingertips. Its high data quality, sample compatibility and automated software enables drug discovery and inroads into R&D. For Ïã¸ÛÁùºÏ²Ê and external users.
Primary Specifications
- Crude samples, harsh chemicals, and particles up to 1000 nmÂ
- Self-contained disposable cartridge and small footprint
- Ultra-fast transition times of 150 ms with reliable determination of off-rates up to 10 s-1
- Superior signal-to-noise ratios (0.01 pg/mm2 at 1 Hz)
- Reliable kinetics and binding affinities (KD) from low pM to low mM with from signals below 1 pg/mm2
- Analyze large ligand to analyte molecular weight ratios up to >1000:1
- Up to 120 hours of unattended operation
Detailed specifications
Breakthrough Binding Kinetics Analysis
- Expands affinity range and sample compatibility.
- Enhances drug discovery and R&D through high data quality and sophisticated software.
Real-Time Label-Free Binding Kinetics
- Combines robustness for crude samples, high sensitivity, and advanced software.
- Innovative microfluidics and proprietary Grating-Coupled Interferometry (GCI) technology.
High Sensitivity
- Superior to SPR in reading refractive index changes, leading to higher sensitivity.
- Waveguide's evanescent field minimizes bulk disturbances, ensuring high signal-to-noise ratios.
- Measures kinetics (ka, kd) and affinity (KD) from low pM to low mM, even from very low signals (<1RU).
Temperature-Controlled Autosampler
- Can handle various sample formats (vial racks, well plates).
- Allows sensitivity with low immobilization levels and large ligand-to-analyte MW ratios.
Large Ligand-to-Analyte Molecular Weight Ratios
- Suitable for large target-to-analyte molecular weight ratios up to >1000:1.
- Ensures accurate kinetic analysis of low-potency small molecules or targets with low activity.
More Signal, Less Noise
- GCI's evanescent field reduces bulk refractive index disturbances.
- Results in superior signal-to-noise ratios.
Robust Readout
- Time-domain interference readout within the waveguide offers robustness.
- Time-resolved phase-shift signal measurement provides superior resolution despite temperature drifts or vibrations.
Bookings
All Ïã¸ÛÁùºÏ²Ê staff and students can book this equipment through Outlook. Bookings are made by the hour starting on the hour.
Please contact Dr Ramin Sadri (R.Sadri@ucl.ac.uk) for details.
Once you are registered as a user, please provide the following mandatory information when you book.
Internal bookings
- Full name
- Department
- Your Finance Officer's name
- Account code for charges
- The equipment you wish to use
- Hours / dates required
External bookings
- Full name
- Company address and department name
- Finance contact details: address, telephone number and email
- PO numberÂ
- PO Description: equipment name, date and hours booked
- VAT number
- Amount
Image credit
Creoptix / Malvern Panalytical