Immune Dynamics after Repeated Influenza Vaccination
Report on the outcomes of research into Immune Dynamics after Repeated Influenza Vaccination, supported by the Ïã¸ÛÁùºÏ²Ê Grand Challenges and the University of Hong Kong.
1 February 2019
Report on the outcome of the Hong Kong cohort arm of a joint HKU-Ïã¸ÛÁùºÏ²Ê study of influenza dynamics, supported by the University of Hong KongÌýand Ïã¸ÛÁùºÏ²Ê Grand Challenges
Prior to the 2009/10 influenza season, 796 children were enrolled in a cohort study. 367 were followed for five years and gave blood samples every six months. The project team explored the trajectories of HAI antibody titers.
Deliverable 1
Statistical analyses to study the effect of repeated influenza vaccination on antibody waning in both the HK and UK cohorts, specifically:
- To estimate the antibody waning after repeated vaccination over time;
- To estimate the correlation of HAI titer with protection against laboratory-confirmedÌýinfection; and
- To determine whether this protection differs between individuals who received multipleÌýinfluenza vaccinations over the years
Figure 1. Influenza HAI antibody titer measured in same individuals every 6 months over five years since their last influenza vaccination or PCR-confirmed influenza A/B virus infection.
A) Individuals who have reported never receive an influenza vaccination, nor had a PCR-confirmed influenza A/B virus infection.
B) Individuals who had reported received at least once influenza vaccination but did not have a PCR-confirmed influenza A/B virus infection. pH1: Influenza A(H1N1pdm09); sH3: A(H3); B.Vic: Influenza B(Victoria); B.Yam: B(Yamagata).
Ìý
Deliverable 2
To organise twoÌývirtual half-day workshops with a consortium of multi-disciplinary scientists, to:
- Identify a unifying research agenda and future funding opportunities
- Establish a writing group to develop applications forÌýfurther grant funding
The team have now met three times (inÌýNew York, London and Stockholm)Ìýto discussÌýthe project and future research directions.