In the Linden Lab, based at the Ïã¸ÛÁùºÏ²Ê Ear Institute, we research the brain mechanisms of listening.
Our work
We investigate how complex, temporally varying sounds (such as speech) are represented and analysed by neurons in the auditory cortex and thalamus.
We also study how brain mechanisms of listening are disrupted in mouse models of human schizophrenia, tinnitus and auditory processing disorder.
Our goal is to translate fundamental discoveries in mice into new tools and treatments for improving listening ability in humans. Experimental methods include electrophysiological recording, computational modelling, and auditory behavioral testing in mice and humans.
Research projects
We believe the best science and greatest impact arises from cross-fertilisation of ideas, between people and across disciplines. Our projectsÌýare interdisciplinary, and involve collaborations with colleagues at Ïã¸ÛÁùºÏ²Ê and/or around the world. Find out about our current projects
- Brain mechanisms of listening
- Auditory brain abnormalities in developmental disorders
- Auditory brain abnormalities in schizophrenia
- Other ongoing work
Find out more about our research.
±Ê±ð´Ç±è±ô±ðÌý
Adele Simon, postdoctoral student
Ìý
Eleanor Benoit, rotation student
Ìý
Lara Carvalho Sauer, MSc Advanced Audiology project student
Lior Fox,Ìýpostdoctoral fellowÌý
Selected recent publications
- Lu C and Linden JF (2023).ÌýÌýbioRxiv,Ìýdoi: 10.1101/2023.10.04.560916.
- Akritas M, Armstrong AG, Lebert JM, Meyer AF, Sahani M and Linden JF (2023). ÌýbioRxivÌý2023.04.22.537782; doi: 10.1101/2023.04.22.537782.
- Linden JF (2023). Sensory representations in the auditory cortex and thalamus. Section 5, Chapter 7 in: Usrey WM (Ed.), Sherman CM (Ed.), Hirsch J (Section Ed.) and King AJ (Section Ed.),ÌýThe Cerebral Cortex and Thalamus.ÌýOxford University Press, in press.
- Zinnamon FA, Harrison FG, Wenas S, Liu Q, Wang KH and Linden JF (2023). ÌýBiological Psychiatry: Global Open Science, 3:386-397.
- Wang B, Zartaloudi E, Linden JF and Bramon E (2022).Ìý ÌýTranslational Psychiatry, 12(1):100.
- Gothner T, Goncalves PJ, Sahani M, Linden JF and Hildebrandt KH (2021). ÌýCerebral CortexÌý31(5):2364-2381.
- Kopp-Scheinpflug C and Linden JF (2020). Coding of Temporal Information. In: Fritzsch B (Ed.) and Grothe B (Volume Ed.),ÌýThe Senses: A Comprehensive Reference, Volume 2 (Audition).ÌýElsevier, Academic Press, pp. 691-712. (ContactÌýj.linden@ucl.ac.ukÌýto request a reprint.)
- Zinnamon FA, Harrison FG, Wenas SS, Meyer AF, Liu Q, Wang KH and Linden JF (2019). ÌýbioRxivÌýdoi: 10.1101/539650.
- Meyer AF*, Poort J*, O'Keefe J, Sahani M and Linden JF (2018). ÌýNeuronÌý100:46-60.e7.Ìý*equal contributions
- Kopp-Scheinpflug C, Sinclair JL and Linden JF (2018). Trends in NeurosciencesÌý41:712-728.
- Anderson LA*, Hesse LL*, Pilati N*, Bakay WMH, Alvaro G, Large CH, McAlpine D, Schaette R, and Linden JF (2018). ÌýHearing ResearchÌý365:77-89.Ìý*equal contributions
- Hildebrandt KJ, Sahani M and Linden JF (2017). ÌýFrontiers in Systems Neuroscience, 29 November 2017, doi:10.3389/fncir.2017.00095.Ìý
- Guidi LG, Mattley J, Martinez-Garay I, Monaco AP, Linden JF, Velayos-Baeza A and Molnar Z (2017). ÌýCerebral CortexÌý17:1-15.
- Burgess CP, Lak A, Steinmetz N, Zatka-Haas P, Reddy CB, Jacobs E, Linden JF, Paton JJ, Ranson A, Schroeder S, Soares S, Wells M, Wool LE, Harris KD, Carandini M (2017).Ìý Cell ReportsÌý20(10): 2513-2524.
- Linden JF (2017). ÌýNeuronÌý95(1): 3-5.
- Meyer AF, Williamson RS, Linden JF and Sahani M (2017). ÌýFrontiers in Systems NeuroscienceÌý10(109), doi: 10.3389/fnsys.2016.00109.Ìý
- Hesse LL, Bakay W, Ong HC, Anderson LA, Ashmore J, McAlpine D, Linden JF and Schaette R (2016). ÌýFrontiers in NeurologyÌý7(133), doi: 10.3389/fnrur.2016.00133.Ìý
- Williamson RS, Ahrens M, Linden JF* and Sahani M* (2016). ÌýNeuronÌý91(2): 467-71.Ìý*equal contributions
- Anderson LA and Linden JF (2016). ÌýJournal of NeuroscienceÌý36(6): 1977-95.
View older publications
Funding
We are grateful to have received funding for past projects from the following bodies:
Currently, our research on fundamental brain mechanisms of listening is funded by the BBSRC, and our translational work on development of new algorithms to improve human listening ability is funded by the NIHR-Ïã¸ÛÁùºÏ²ÊH Biomedical Research "Hearing Health" Theme.