Deep phenotyping - Imaging and functional testing in clinic, remote assessment and wearables
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What?
Ìý
Why?
Ìý
How?
Multi-organÌýimagingÌý
Imaging of the brain, lungs, heart,ÌýliverÌýand kidneys usingÌýmagnetic resonanceÌýimaging (MRI)
Functional testing in clinic Ìý
- ÌýAnthropometryÌý
ÌýLung function usingÌýspirometryÌýÌý
RestingÌýheart rate variability and electrocardiogram (ECG),Ìýlying, seated, standing brachialÌýand centralÌýblood pressure (BP)Ìý
Cardiopulmonary exercise testing, including assessment of peak VO2, 12 lead ECG, blood pressure, muscle perfusion using near infraredÌýspectroscopy, echocardiographic cardiacÌýoutputÌýand pre/post-exercise lactateÌý
ÌýRetinal Optical Coherence Tomography angiographyÌýÌý
ÌýStrength and physical performanceÌý
ÌýBloodÌýand urineÌýsamplesÌýfor storageÌý
Remote assessmentÌýand wearables
ÌýMassSciÌýAppÌýfor remote assessmentÌýofÌýphysical and mental health fortnightly or monthly, depending on the parameter measured.Ìý
CognitronÌý()ÌýforÌýcognitive function, completed weekly for a month, and subsequently repeated 6 monthly.Ìý
GarminÌývivoactiveÌý4 wrist worn deviceÌýtoÌýcaptureÌýhabitualÌýactivity, heart rate variability, sleep patterns, oxygen saturation (SpO2) and respiratory rate. In addition,Ìýparticipants willÌýperform a standardised 6-minute walk test and a chair sit-stand test fortnightly for theÌýfirstÌý6 months, then quarterly. AllÌýremoteÌýassessments will continue for up to 18 months.Ìý